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Several factors affect warfarin dosage, including age, body weight, concomitant medications, and DNA sequence variants in cytochrome P450 2C9 ( CYP2C9 ) and vitamin K epoxide reductase subunit 1 ( VKORC1 )

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Herein, we outline the role of several nutrients known to contribute to prostate tumorigenesis, including fatty acids, glucose, lactate and glutamine, and discuss the major factors contributing to variability in prostate cancer metabolism, including cellular heterogeneity, genetic drivers and mutations, as well as complexity in the tumor microenvironment