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The same study also showed that around 30% of those taking oral semaglutide achieved 20% weight loss or more, compared with around 3% on placebo, and approximately 76% of participants achieved at least 5% body weight loss
While this is generally not clinically significant, patients on multiple blood pressure medications should be monitored for hypotension, particularly if initiating magnesium supplementation alongside GLP-1 therapy, which may also contribute to modest blood pressure reductions through weight loss
Some patients report that taking their GLP-1 medication before bed allows them to sleep through the period when side effects might be most noticeable, waking with reduced symptoms
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