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Free cobalamin is stored in the liver and kidney [17] and is excreted through the kidney

This synergy is under exploration in models studying aging, metabolic health, and endurance performance

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It is an essential nutrient which is water soluble

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In cases where absorption is compromised, high oral doses or very high doses (such as 1,0002,000 mcg) of vitamin B12 may be required to correct deficiency, as these can sometimes be effective alternatives to injections