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Paris 93 (6), 467477

doi: 10.1007/s00296-008-0569-9

In HEK293T cells, UBE2O overexpression leads to a dose-dependent reduction of endogenous BMAL1, while its knockdown increases BMAL1 protein levels ( UBE2O overexpression attenuates BMAL1-driven transcription and dampens downstream circadian outputs, while its silencing increases PER2 rhythm amplitude, confirming its role in maintaining clock dynamics (Maffeo and Cilloni, 2024)

Thus, they have been typically utilized for the loading and delivery of small-molecule antibiotics [178,179,180]

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