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The Q-Exactive + - Orbitrap-MS, equipped with a HESI probe, was set up with the following parameters: a heat temperature of 425 C, sheath gas at 30, auxiliary gas at 13, sweep gas at 3, a spray voltage of 3.5 kV in positive mode, a capillary temperature of 320 C, and an S-lens setting of 45

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Innovative avenues include immunotherapy targeting nociceptorimmune crosstalk, ferroptosis modulation, microbiota manipulation, and diet-based metabolic strategies

Methods: A narrative review with a structured literature search was conducted using PubMed, Embase, and Cochrane Library databases from inception to March 2025

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No severe adverse events have been reported in published NAD+/NADH trials