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Pharmacological potential of three berberine-containing plant extracts obtained from Berberis vulgaris L., Mahonia aquifolium (Pursh) Nutt., and Phellodendron amurense Rupr
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After 2 weeks of treatment, mice treated with GLP-1MK-801, as well as those subjected to calorie restriction or GLP-1 monotherapy, demonstrated enhanced glucose tolerance compared with mice that were treated with the vehicle or MK-801 monotherapy (Extended Data Fig
& Shen, Z
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While glucose is the obligatory fuel, ketone bodies can also be used by the brain when glucose supply is inadequate, such as during prolonged fasting or starvation
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