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Mechanistically, activated HSCs secrete GLUT1-containing exosomes in response to hypoxia-inducible factor (HIF) 1, which are subsequently taken up by unactivated HSCs, promoting glucose uptake and glycolysis and facilitating HSC activation

Appl Immunohistochem Mol Morphol 19(3):239245

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The Fc-fusion architecture implies a dosing cadence longer than weekly, plausibly every-two-weeks or monthly, which differentiates on convenience if efficacy holds

Ascorbyl stearate was found to be more potent than sodium ascorbate in inhibiting proliferation of human glioblastoma cells [80]