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Sampson CM, Dimet AL, Neelakantan H, et al

It does not replace one

When you reach the age of 65, you are much more likely to suffer from medical conditions, like atrophic gastritis, that reduce the ability to produce stomach acid

Further research is required to characterize the biological mechanisms associated with NNMT inhibition and the broader implications of these findings

In obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and lowering NAD+ availability [2]

The elevated B12 appears to be a consequence of disease activity, likely resulting from increased production of B12-binding proteins by tumor cells or from liver involvement in the cancer process