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The most extensively researched risk variables were environmental factors such cariogenic bacteria, a diet heavy in carbohydrates, and inadequate dental hygiene (157159)

Glutamine deprivation or genetic deletion of c-Myc, a key transcription factor that plays a role in regulating T cell metabolic reprogramming, impairs the biosynthesis of polyamines and nucleotides in T cells [3]

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Karasawa, J., Shimazaki, T., Kawashima, N