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June 2024: Structure Therapeutics reported positive Phase IIa obesity data for GSBR-1290, an oral non-peptide small-molecule GLP-1 receptor agonist, achieving 6.2% placebo-adjusted mean weight loss at 12 weeks

doi: 10.1016/j.ejmech.2020.112675 10 BlancWARosenblattPWolffJA

These data on changes in bone metabolism are important because they allow us to put things into perspective in the context of GLP-1Ra for obesity care

The magnitude of metabolic improvements with tirzepatide may justify higher costs if these translate into meaningful clinical outcomes

Thereafter, it is transformed into homokaryotic spores by a Cre (recombinase)-expressing plasmid to introduce the deletion or mutation into target genes for their functional study, as well as metabolic improvement (Table 3)