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In particular, under hypoxic conditions, Gln consumption is elevated, and Gln carbon is mainly used for fatty acid production through the reductive carboxylation of KG and citrate synthesis [83,84,85], whereas the Gln-derived nitrogen is expelled from cells in the form of dihydroorotate to prevent ammonia-induced toxicity [85]

At higher pH levels, cysteine can form disulfide bonds with other cysteine residues in the same peptide or even in neighboring peptide molecules