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BPC-157 , , ( )

Junctional epidermolysis bullosa Junctional epidermolysis bullosa (JEB) is an autosomal recessive type of EB with an estimated incidence of 2.68 per million live births and an estimated prevalence of 0.49 per million individuals in the United States.[140] A Dutch EB registry study reported higher JEB prevalence estimates, with JEB occurring at a rate of 9.3 per million live births and 2.1 per million individuals in the Netherlands.[129] In this study, approximately 19% of all EB diagnoses were JEB

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Three major functional domains represent the essence of the KEAP1 protein structure: the N-terminal Broad complex/Tramtrack/Bric brac (BTB) domain, the central intervening region (IVR) and the C-terminal Kelch/Double glycine repeat (DGR) domain [121, 122]