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Finally, berberine is strictly contraindicated for pregnant women, as it can cross the placenta and has been linked to kernicterus (a form of brain damage) in newborns

CDC.gov, Candidiasis

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This instability impacts their half-life in the body and their efficacy

Ophthalmic Epidemiology

[18] Lactation studies demonstrate that maternal injections modestly elevate breast-milk B12 concentrations without adverse infant outcomes, supporting compatibility with breastfeeding while underscoring the need for maternal repletion to prevent neonatal deficiency