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This triple-receptor activity distinguishes retatrutide from earlier incretin mimetics such as semaglutide (a pure GLP-1 agonist) and tirzepatide (a dual GIP/GLP-1 agonist)

described receptor binding, signaling profile, and proof-of-concept pharmacology in preclinical systems

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Larger independent studies would strengthen the evidence base

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A comparison of the effects of the Latham-Millard procedure with those of a conservative treatment approach for dental occlusion and facial aesthetics in unilateral and bilateral complete cleft lip and palate: part I