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Grape seed proanthocyanidin extracts enhance endothelial nitric oxide synthase expression through 5'-AMP activated protein kinase/Surtuin 1-Krpple like factor 2 pathway and modulate blood pressure in ouabain induced hypertensive rats
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For patients taking semaglutide who have not achieved desired weight loss, ensuring adequate dose titration to the maximum tolerated dose (2.4 mg weekly for Wegovy) and allowing sufficient treatment duration (at least 16-20 weeks) is essential before adding additional pharmacotherapy