although human relevance remains uncertain, patients with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN2) are generally advised not to use GLP-1 RAs
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Efficacy and Safety of GLP-1 Receptor Agonists, Dual Agonists, and Retatrutide for Weight Loss in Adults With Overweight or Obesity: A Bayesian Network Meta-Analysis
Annualized, that's $15,000 to $18,000
Going from 0.25mg to 0.50mg simply means doubling from 10 units to 20 units