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In the Phase 2 trial protocol, participants began at a low starting dose commonly 2 mg once weekly before progressing through incremental increases over several months, with target maintenance doses ranging from 8 mg to 12 mg weekly depending on tolerability and clinical response

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Available from: European Medicines Agency (EMA) (2023) Xultophy

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For example, certain microbial metabolites (like SCFAs) can promote -syn aggregation in enteric neurons, as shown in one mouse study [95]