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Downregulation of the activity of a number of CoA-dependent acyltransferases has been reported in HSL-null mice, and it is believed to contribute to maintenance of normal weight in the face of complete ablation of this important lipolytic enzyme (144)

Osteopontin, for example, is involved in both inflammatory responses and bone remodeling and metabolism, and it also affects the nervous system, playing a dual role in tissue damage and repair

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