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Crucially, there is no established evidence base for efficacy at low doses specifically for inflammation, and the dose-response relationship for anti-inflammatory effects is unknown

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This can be important for older individuals or those with very low NAD (where a big replenishment is needed)

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[ 13 ] Separate research in old monkeys showed that Epitalon increased basal nighttime melatonin levels and also improved age-related changes in glucose and insulin regulation