glp-1 medications side effects temporary or long-term Adverse of Receptor Agonists Ozempic and GLP-1 Drugs: Risk

Neuroscience 158:514523 Calabrese V, Giuffrida Stella AM, Calvani M, Butterfield DA (2006) Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes

Zhou et al., 2019

Folli F, Finzi G, Manfrini R, et al

The downsides are nausea, vomiting, upset stomach, and hair loss in some patients

These associations involve chronic endogenous elevation, but they establish the biological plausibility of concern for long-acting exogenous analogues [8]

That said, if medication nonadherence was a major factor for the blunted glycemic outcomes, the question remains why GLP-1 analog therapy did mediate significant weight loss, especially in women and SSRI users