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TYPE B OR IDIOSYNCRATIC ADVERSE DRUG REACTIONS : Paracetamol: An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate PARACETAMOL: AN EXAMPLE OF A DRUG THAT CAUSES TOXICITY THROUGH THE FORMATION OF A CHEMICALLY REACTIVE INTERMEDIATE For many drugs that undergo metabolism, CRM will be formed irrespective of the dose of the drug (Pirmohamed, Madden and Park, 1996)