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[11][12] This increase in IGF-1, brought on through consistent application of RK, could regulate keratinocyte differentiation, improve dermal insulin resistance, up-regulate 5-Reductase which in turn would increase sebocyte proliferation, and also promote hair follicle growth [1][10][12][15][19]

In contrast, knockdown of RRM2 significantly inhibited the migration and invasion ability of THCA cells compared with the control group ( Figure 7C , Supplementary Figure S6 )

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36 : 397 - 403 Haber CA, Lam TK, Yu Z, Gupta N, Goh T, Bogdanovic E, Giacca A, Fantus IG