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n = 4,668) or placebo ( n = 4,672), with both groups also receiving standard care (treatment period: 3.55 years)

Cigarette smoke can reduce the expression of Frizzled receptor 4 (FZD4) in alveolar epithelial cells and enhance the phosphorylation of -catenin, inhibiting epithelial proliferation and alveolar repair mediated by the classic Wnt signalling pathway

Capsules may appeal to patients who want convenience, while injections are often discussed for more direct delivery

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