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Under conditions of oxidative stress or in the presence of an Nrf2 activator, Nrf2 and Keap1 separate, and Nrf2 travels to the nucleus where it binds to the antioxidant response element gene

As Glp1r Tie2/ mice exhibited marked reduction in IEL Glp1r expression (Figure 1D), we assessed whether more selective reduction of IEL GLP-1R expression, as opposed to loss of the entire IEL population and systemic consequences arising from loss of integrin 7, would upregulate plasma levels of GLP-1

October 25, 2024

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