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(PubMed) Ohno S, Ohno Y, Suzuki N, Soma G, Inoue M

World journal of gastroenterology , 28 (1), 23-46

In 2023, the FDA placed approximately 1719 peptides on the Category 2 restricted list citing safety concerns: potential carcinogenicity, immunogenicity risk, organ toxicity, and a lack of clinical trial data in humans

The rationale for combining them is mechanistic complementarity

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The rationale rests more on theoretical benefit and observed clinical patterns than controlled trial evidence