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It is secreted following nutrient ingestion, resulting in enhanced glucose-stimulated insulin secretion (GSIS) from the pancreatic -cells as well as delayed gastric emptying and enhanced satiety, making it an attractive target for the treatment of T2D and obesity 3

Pickart, L., Margolina, A., & Moyer, K

Physiology of the Incretin hormones, GIP and GLP-1-regulation of release and posttranslational modifications

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Based on these findings, the SURMOUNT trials program was designed to study TZPs efficacy and safety in the treatment and management of obesity

Biochem J 359:631637 Nagasawa HT, Goon DJ, Muldoon WP, Zera RT (1984) 2-Substituted thiazolidine-4( R )-carboxylic acids as prodrugs of l-cysteine