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Metformin was also demonstrated to alter expression of genes involved in metabolism, specifically inhibition of oxidative phosphorylation genes, supporting functional analyses and highlighting metformin as a metabolic modulator in rectal cancer

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For thicker subcutaneous tissue, slightly longer needles ensure reliable subcutaneous rather than intradermal placement

= 0.37, P = 0.046), with older participants demonstrating greater TMAO increases from baseline to 24 h