In 2012, while investigating the mechanism of Erastin-induced cell death, Dixon and colleagues formally coined the term ferroptosis to describe this iron-dependent, lipid peroxidation-mediated form of regulated cell death ( Compared with other forms of cell death, such as autophagy, apoptosis, and pyroptosis, ferroptosis exhibits distinct morphological, biochemical, and immunological characteristics (Xia et al., 2025)
doi: 10.1155/2021/9914652 159 YangX
The compound likely acts through various chemical paths and even influences gene activity
It supports liver and kidney function, which are essential for optimal detoxification
In addition to its requisite role in fatty acid oxidation, it can facilitate glucose disposal by modifying the mitochondrial acetyl-CoA/CoA ratio [8]
Pancreatitis and pancreatic cancer in patients with type 2 diabetes treated with glucagon-like peptide-1 receptor agonists: an updated meta-analysis of randomized controlled trials