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It has been postulated that these clinical features may arise from the accumulation of potentially toxic substrates, particularly in the so-called intoxicating IEMs, or alternatively due to product deficiency [5]

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Vasculogenesis is also described in adults during capillary formation post ischemia [41] or in tumors as alternative mechanism for neo-vascularization to meet the increasing need for oxygen and nutrient supply [42]

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