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Last reviewed: May 21, 2026 Last updated: May 21, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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Gastrointestinal Adverse Events GI AEs are the most frequently reported side effects of GLP-1 RAs and, although typically mild, moderate, and transient, they remain the primary reason for treatment discontinuation among individuals with obesity receiving semaglutide [13, 27, 38, 40,41,42,43,44,45,46, 52]

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It increases sex hormone-binding globulin in some contexts while paradoxically reducing it in others, creating unpredictable fluctuations in bioavailable testosterone