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All published evidence is from animal or in vitro studiesno peer-reviewed human clinical trials have been completed as of 2026

Hanigan, M

These local hepatic alterationswhen coupled with systemic inflammation, dysregulated adipokines (e.g., leptin, adiponectin), and circulating profibrotic cytokines (e.g., TGF-, IL-13)amplify fibrotic signaling across distant organs (123, 129)

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Another curative function of the HO-1 is to facilitate the conversion of heme into BV, Fe 2+ and CO in equimolar quantities, thus promoting efficient antioxidant and anti-inflammatory effects [50]

JAMA 332, 19411943