downside to semaglutide Losing muscle, as well as fat, is an unexpected of the popular weight-loss drugs that isn't broadly discussed or immediately apparent. “We are curing obesity by encouraging frailty.” 🔗: https://on.wsj.com/49EvpSu I Microdosed Semaglutide at 0.1

GLP-1 Drugs and Triathlon Performance: What Ozempic Really Does to Athletes May 15, 2026 GLP-1 medications like semaglutide (Ozempic, Wegovy) can significantly affect triathlon performance by suppressing appetite, slowing gastric emptying and increasing the risk of muscle loss and chronic under-fuelling

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Medicines with a narrow therapeutic index may require additional monitoring, and warfarin may require more frequent INR monitoring when initiating GLP-1 therapy

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Accordingly, treatment with GLP-1RAs should not result in an unacceptable 80% excess in CV risk compared with placebo (added to standard of care) (FDA Background Document, 2018