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doi: 10.3390/ijms22030988

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Patients with certain genetic profiles may tolerate slower dose escalation, benefit from preventive acid management, or respond better to alternative GLP-1 compounds

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So I will go first with that one

Similarly, genetic variants affecting metabolic rate (FTO rs9939609) and appetite regulation (MC4R rs17782313) can support a more informed conversation with your provider about realistic timelines for weight change and side effect management when combined with sertraline