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Since supplementation with vitamin B12 effectively reverses these immunological impairments, it is hypothesized that the vitamin may function as a modulatory agent in the regulation of cellular immune responses [82,83,84]

104 KimS.ChangL.Weinstock-GuttmanB.GandhiS.JakimovskiD.CarlE.et al (2018)

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However, higher primates (including humans), most bats, guinea pigs, some fish species, and some bird species must acquire it from dietary sources because a gene for a synthesis enzyme has mutations that render it dysfunctional

The microchannels created by needling allow the peptide to bypass the skin barrier and penetrate directly into the dermis dramatically increasing absorption compared to surface application alone