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Obesity as a disease
Pre-clinical and mechanistic studies on cognitive disorders, substance-use disorders, psychotic disorders, mood and anxiety disorders, and eating disorders (Supplementary Table 5
Enhancement of peptide coupling to hydroxyapatite and implant osseointegration through collagen mimetic peptide modified with a polyglutamate domain
Cruz-Maya The anti-inflammatory drug ibuprofen is considered to be an emerging contaminant because of its presence in different environments (from water bodies to soils) at concentrations with adverse effects on aquatic organisms due to cytotoxic and genotoxic damage, high oxidative cell stress, and detrimental effects on growth, reproduction, and behavior
Overall I like this deal for Pfizer and I imagine they will continue to invest heavily in building out the clinical programs for Metseras portfolio beyond obesity, both to help stem revenue loss from LOEs of ELIQUIS and eventually leverage that commercial footprint towards its budding obesity portfolio.
Specific considerations include: Beta blockers (metoprolol, atenolol, propranolol) lower heart rate by blocking sympathetic stimulation
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