Based on these data, pivotal phase 3 trials comparing icotrokinra with placebo in participants aged 12 years and older with moderate-to-severe plaque psoriasis [ICONIC-LEAD (NCT06095115)] and plaque psoriasis involving difficult-to-treat high-impact sites including scalp, genitals, and hands/feet [ICONIC-TOTAL (NCT06095102)], have been initiated (Table 3)
doi: 10.2174/157340410791321381
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The most extensively studied stilbene is resveratrol (trans-3,5,4-trihydroxystilbene), which has attracted intense interest for its neuroprotective and longevity-enhancing properties
The two primary end points were the percent change in body weight and the percentage of patients with a weight reduction of at least 5%
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