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Deng, Y., et al

No, GLP-1 is not a digestive enzyme but a hormone that influences digestive processes

However, the weight loss with GLP-1 agonists may be more gradual and requires ongoing medication adherence, which can become costly over time

10.1016/S0149-2918(03)80130-3

468 Specifically, these agents can attenuate the excitability of carotid body cells and diminish sympathetic activation, ultimately leading to a reduction in sympathetic responses

The fact that the double-cysteine mutations only partially abolish the physiological function may imply that not all the expressed mutants have an intact disulfide bridge and that the observed conformation is only one possible inactive state on the cell surface, as supported by the EM data and MD simulations below