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To confirm that haem-assisted dimerization of PGRMC1 occurs in solution, we analysed the structure of apo- and haem-bound PGMRC1 by two-dimensional nuclear magnetic resonance (NMR) using heteronuclear single-quantum coherence and transverse relaxation-optimized spectroscopy (Supplementary Figs 6b and 7)

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Originally identified in human plasma, this naturally occurring molecule has become one of the most extensively investigated compounds in regenerative biology research

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Similarly, 3-HAA exerts cytoprotective effects by upregulating the antioxidant enzyme heme oxygenase-1 and inhibiting NO synthase activity [120, 123, 165], suggesting that KP metabolites may initially serve adaptive functions during acute stress