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Semaglutide vs tirzepatide for weight loss in adults with overweight or obesity

Gastrointestinal: The adverse effects most frequently reported and most associated with discontinuation of semaglutide include nausea, vomiting, abdominal pain, constipation, and diarrhea

Onset timeline Most cases of retatrutide skin sensitivity appear within the first 2 to 6 weeks of starting treatment, often coinciding with dose escalation phases

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C., & Inzucchi, S

There are no direct drug interactions between semaglutide and common antidepressants, and clinical trial data show Wegovy is equally effective in people taking antidepressants