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The dependence of tyrosine hydroxylase on BH 4 necessitates the coupling to the action of dihydropteridine reductase (encoded by the QDPR gene: quinoid dihydropteridine reductase) as is the situation for tryptophan hydroxylase (see below) and phenylalanine hydroxylase

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26 One way lysine regulates calcium is through the cholesterol transporter NPC1, which also is needed for autophagythe clearing away of damaged cells to be replaced with new cells

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