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Drug shortages are the result of a complex mix of contributing factors that can include: Manufacturing quality issues Supply chain disruptions Raw material scarcity Increased demand for certain drugs Pricing and regulatory hurdles Geopolitical instability Natural disasters and extreme weather events Some recent examples include a tornado that damaged a Pfizer plant in 2023, halting production of 15 medications, and FDA quality issues that shut down cisplatin production in India, resulting in a nationwide shortage of a critical chemotherapy drug

Users who haven't seen significant improvement by week 12 may need protocol adjustment: higher concentration, different product format, or combination with other treatments

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American Diabetes Association (ADA)

Microbiota in the gastrointestinal tract