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But Don't Discount the Systemic Argument Entirely Now, this is where the nuance comes in

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Image items used in this work were created in BioRender: Ethics declarations Competing interests The authors declare no competing interests

NNMT inhibition or NNMT knockdown significantly increases energy expenditure, reduces body weight and white adipose mass, improves insulin sensitivity, and normalizes glucose tolerance and fasting blood glucose levels

Numerous in vivo studies testing high doses of melatonin reported extremely low toxicities

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