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Using ionizing radiation-induced senescent IMR90 cells, it was observed that FOXO4 maintains senescent cell viability by targeting p53 to the nucleus and preventing it from inducing apoptosis

Typical protocols involve doses ranging from 13 mg daily or several times per week, often cycled in 812 week intervals with breaks to prevent receptor downregulation or potential copper accumulation

Peroxynitrite is a potent oxidant that is generated upon the reaction of superoxide with nitric oxide (NO)

Intranasal delivery may also be inappropriate where there is an impaired level of consciousness