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Acknowledgements The authors wish to thank the staff at the Animal Care Facilities at Galleon Pharmaceuticals, Inc

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Together, these shifts create a coherent endocrine profile favoring energy conservation, characterized by reduced thyroid hormone activation despite stable or only mildly suppressed central HPT signaling

J Mol Neurosci 51:679686 Gilgun-Sherki Y, Melamed E, Offen D (2006) Anti-inflammatory drugs in the treatment of neurodegenerative diseases: current state