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For injectable semaglutide (Ozempic, Wegovy), interactions are primarily indirect, while oral semaglutide (Rybelsus) has documented pharmacokinetic interactions with levothyroxine

Semaglutide is metabolized through protein degradation rather than hepatic metabolism, but alcohol can worsen liver disease and impair the liver's ability to regulate blood glucose

These medications work by mimicking the action of naturally occurring GLP-1 , a hormone released by the intestines after eating

Like other GLP-1 medications, Rybelsus uses a gradual dose increase (i.e

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