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In patients with liposarcoma and leiomyosarcoma receiving HALAVEN, the most common adverse reactions (25%) reported in patients receiving HALAVEN were fatigue (62%), nausea (41%), alopecia (35%), constipation (32%), peripheral neuropathy (29%), abdominal pain (29%), and pyrexia (28%)

Face aux peptides gastroprotecteurs classiques comme le sucralfate ou les inhibiteurs de pompe a protons (IPP), il agit via une voie completement differente : restauration de la microcirculation muqueuse plutot que reduction de l'acidite ou formation d'une couche protectrice mecanique

10.1007/s00018-023-04761-4 214 NjajouO

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As a receptor for prostaglandin E2 (PGE2), Ptger4 mediates downstream Gs proteincoupled signaling cascades that are central to the regulation of immune and inflammatory processes

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