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Because embryonic stem (ES) cells give rise to all the tissues in an organism, mechanisms are in place to avoid the accumulation of DNA to prevent mutations that would transmit to tissues and subsequent generations

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The inhibitor STM2457 can reduce the m6A level in cancer cells by inhibiting the IGFBP3/AKT signaling axis, thus exerting anticancer effects in vitro and in vivo (127)

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