doi: 10.1124/pharmrev.122.000560 128 TuttleKRAgarwalRAlpersCEBakrisGLBrosiusFCKolkhofPet al
The Trx-interacting protein (TXNIP) promotes ferroptosis in mouse models of bronchopulmonary dysplasia [108] , cardiac ischemia/reperfusion injury [109] , sepsis-induced cardiomyopathy [110] , and polycystic ovary syndrome [111]
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Likewise, in datasets GSE135251 ( n = 206) and GSE126848 ( n = 57) unsupervised machine learning discerned a red cluster with increased gene expression for PUFA incorporation, theoretically sensitizing toward ferroptosis, combined with decreased expression of ferroptosis defenses
In two independent experiments utilizing different mouse strains, the AF-treated mice had a 59% and 63% decreases in worm burden compared to control mice (Table 5)
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