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Metabolites with missing data values were removed from the data set, making data imputation unnecessary

This follows the FDAs Clear, Conspicuous, and Neutral (CCN) Final Rule, which introduced stricter standards for how risk information (the major statement) is communicated in DTC broadcast ads

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Among the gene sets, genes with roles in GSH metabolism (KEGG_GLUTATHIONE_METABOLISM, p value, 0.032) were substantially downregulated in Fabry kidney organoids, indicating that the molecular functions were relatively deactivated

The medication reaches steady-state concentrations, providing consistent therapeutic effects