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This study aimed to investigate the mechanism of antinociception and the effects of the GLP-1 agonist semaglutide (SEMA) on diabetic neuropathic pain in diabetic rats

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Kok P., Roelfsema F., Langendonk J.G., Frlich M., Burggraaf J., Meinders A.E., Pijl H

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Complex, because the variables that interact to determine energy balance - hormonal, physiologic, genetic, neurological, psychological, cultural, familial, environmental, societal - in short nature plus nurture - are impossible to disentangle and control

The article says rapid escalation can trigger nausea, vomiting, and dehydration, and that the risk runs higher in people with slower gastric emptying or pre-existing gastrointestinal conditions